GENTAMYCIN SULPHATE INJECTION
Gentamycin is an aminoglycoside antibiotic used, usually in combination, to treat severe systemic infections due to sensitive Gram-negative and other organisms. They include biliary- tract infections, brucellosis, endometritis, gastroenteritis, cystic fibrosis, as well as in the prophylaxis of surgical infection and the treatment of immunocompromised patients those in intensive care.
Gentamycin sulphate is commonly given intramuscularly every 8 hours to provide a total daily dose of 3 to 5mg of gentamicin per kg body-wedght. It may be given intravenously in similar doses to those used intramuscularly.
The aminoglycosides can produce irreversible, cumulative ototoxicity affecting both, the cochlea and the vestibular system. The incidence and relative toxicity with different aminoglycosides is a matter of some dispute, but netilmicin is probably less cocUeotoxic than gentamycin or tobramycin, and amikacin more so, and netilnicin also exhibits less vestibular toxicity than gentamycin, tobramycin, or amikacin while streptomycin produces a high incidence of vestibular damage, Vestibular damage is more common than hearing loss in patients receiving gentamycin.
Gentamycin is contra-indicated in patients with a known history of alle^y to it, and probably in those allergic to other aminoglycosides. Great care is required in patients with myasthenia gravis, parkinsonism, and other conditions characterized by muscular weakness. Topical application of gentamyicin is contra-indicated in patients with known or suspected perforation of the ear drum. Use of aminoglycosides during pregnancy may damage the 8th cranial nerve of the fetus.
Store in a cool & dark place.
Protect from light.