Chloroquine Phosphate injection
It is a clear sterile solution of Chloroquine Phosphate Each ampoule of 2 ml contains
129 mg Chloroquine Phosphate (approximately equivalent to 80 mg Chloroquine base),
Each ampoule of 5 ml contains 250 mg Chloroquine Phosphate (approximately equivalent
to 155mg Chloroquine base) or each ampoule of 5 ml contains 322.5 mg Chloroquine
Phosphate (approximately equivalent to 200 mg Chloroquine base).
ACTIONS AND USES:
Chloroquine Phosphate injection is one of the most powerful and rapid acting
antimalarials. It can kill the asexual forms of various malaria protozoa and is highly effective
in the control of the clinical symptoms of malignant tertian and quartan malaria. It is mainly
used to rescue severe malarial patients or those unable to take medicine orally. In case of
vomiting or other causes. Chloroquine Phosphate is readily absorbed in the human body
and a considerable proportion is retained in the tissue cells of the internal organs, and it is
ADMINISTRATION AND DOSAGE:
The dosage of this drug should be calculated strictly according to the body weight of
the patients, especially for children, and it should be reduced adequately for children with
general weakness, for babies or old patients. Chloroquine phosphate injection should not
be used or should be used with great care in Patients with severe hepatic, renal or cardiac
By intramuscular injection:
Children: 2-3mg of Chloroquine base per kg body weight once daily. For the sake of
safety, this daily dose may be given in two injections at half an hour interval.
Adults: Usually once daily, 2-3 mg Chloroquine base per kg body weight and may be
repeated after 8 hours, the total daily dose should not exceed 6 mg (base) per kg body
By intravenous instillation:
This method of administration is only applied for rescuing patients with cerebral malaria
or in emergency. A dose of 2-3mg of Chloroquine base per kg body weight is diluted with
thorough shaking in 500 ml isotonic sodium chloride solution or 5% dextrose solution and
is then injected slowly at a rate of NOT MORE THAN 20 DRIPS PER MINUTE FOR
CHILDREN and NOT MORE THAN 40 DRIPS PER MINUTE FOR ADULTS. This dose
may be repeated after 8 hours, but the total daily dose should not exceed 6 mg (base) per kg
body weight. The dosage for any adult patient over 50 kg is calculated according to 50 kg
Chloroquine Phosphate Injection may cause a temporary fall of blood pressure, increase
of pulse rate and adverse reactions such as vertigo, headache, nausea, vomiting, obscure
vision and local pain.
1. Chloroquine Phosphate Injection, if given in over dose or injected too rapidly, may
produce severe toxic effect. For this reason, the injection should only be used in patients
who are unable to take medicine orally, close attention must be paid to avoiding over dose.
In intramuscular injection, be sure that the drug is not injected into the blood vessel. As
soon as the patient becomes better and is able to swallow, oral doses of Chloroquine Tablets
or Syrup should be given instead.
2. Chloroquine Phosphate Injection should not be mixed with drug like Quinine
Dihydrochloride which will cause a fall of blood pressure and at the same time no other
antimalarial drug should be used.
3. After injection of Chloroquine Phosphate, for safety sake, the patient should rest for
half an hour under medical care in the clinic.
In boxes of 10 or 50 ampoules of 2 ml containing 129 mg Chloroquine Phosphate (80 mg
base), in boxes of 5 or 100 ampoules of 5 ml containing 250mg Chloroquine
Phosphate (155mg base) or in boxes of 5 or 100 ampoules of 5ml containing 322.5 mg
Chloroquine Phosphate (200 mg base).
It should be kept in well-closed containers and protected from light.
Mercator's Other popular Antimalarial products according to the WHO guidelines include:
1. Arteether Injection
2 Artemether + Lumefantrine Powder for Suspension
3. Artemether + Lumefantrine Tablets
4. Artemether Injection
5. Artemisinin + Piperaquine Tablets
6. Artesunate + Amodiaquine Tablets
7. Artesunate + Mefloquine Tablets
8. Artesunate + Sulfadoxine + Pyrimethamine Tablets
9. Chloroquine Phosphate Injection
10. Dihydroartemisinin + Piperaquine Phosphate + Trimethoprim Powder for Suspension
11. Dihydroartemisinin + Piperaquine Phosphate + Trimethoprim Tablets
12. Dihydroartemisinin + Piperaquine Phosphate Powder for Suspension
13 Dihydroartemisinin + Piperaquine Phosphate Tablets
14. Quinine Dihydrochloride Injection
15. Sulfadoxine + Pyrimethamine Tablets