Sulfadoxine + Pyrimethamine Tablets

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Sulfadoxine + Pyrimethamine Tablets

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Sulfadoxine + Pyrimethamine Tablets

Product description

Details:

Sulfadoxine 500mg + Pyramethamine 25mg is an antimalarial agent which acts by reciprocal potentiation of its two components, achieved by a sequential blockade of two enzymes involved in the biosynthesis of folinic acid within the parasites. It is effective against certain strains of Plasmodium falciparum that are resistant to chloroquine. Both the sulfadoxine and the pyramethamine are absorbed orally and are excreted mainly by the kidney. Following a single tablet administration, sulfadoxine peak plasma concentrations of 51 to 76 mcg/mL were achieved in 2.5 to 6 hours and the pyramethamine peak plasma concentrations of 0.13 to 0.4 mcg/mL were achieved in 1.5 to 8 hours. The apparent half-life of elimination of sulfadoxine ranged from 100 to 231 hours with a mean of 169 hours, whereas pyramethamine half-lives ranged from 54 to 148 hours with a mean of 111 hours. Both drugs appear in breast milk of nursing mothers.

Product Packaging
Sulfadoxine + Pyrimethamine Tablets can be packaged as:
3 Tablets / Blister / Box
10 Tablets / Blister, 10 Blisters / Box or
1000 Tablets / Bottle
or according to the customer's requirements
  • Antimalarial
  • Sulfadoxine / Pyrimethamine
  • China
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Product Dosages

 

NameFormDosageCode
Sulfadoxine + Pyrimethamine  Tablet  500mg + 25mg 1000.0537 
Additional Information

METHATOR
Sulfadoxine 500mg + Pyrimethamine 25mg Tablets

CLINICAL PHARMACOLOGY
Methator is an antimalarial agent which acts by reciprocal potentiation of its two components, achieved by a sequential blockade of two enzymes involved in the biosynthesis of folinic acid within the parasites. Methatoris effective against certain strains of Plasmodium falciparum that are resistant to chloroquine. Both the sulfadoxine and the pyrimethamine of Methatorare absorbed orally and are excreted mainly by the kidney. Following a single tablet administration, sulfadoxine peak plasma concentrations of 51 to 76 mcg/mL were achieved in 2.5 to 6 hours and the pyrimethamine peak plasma concentrations of 0.13 to 0.4 mcg/mL were achieved in 1.5 to 8 hours. The apparent half-life of elimination of sulfadoxine ranged from 100 to 231 hours with a mean of 169 hours, whereas pyrimethamine half-lives ranged from 54 to 148 hours with a mean of 111 hours. Both drugs appear in breast milk of nursing mothers.

INDICATIONS AND USAGE
Methator is indicated for the treatment of P. falciparum malaria for those patients in whom chloroquine resistance is suspected. Malaria prophylaxis with Methatoris indicated for travelers to areas where chloroquine-resistant P. falciparum malaria is endemic. However, strains of P. falciparum may be encountered which have developed resistance to Metator.

CONTRAINDICATIONS
Prophylactic (repeated) use of Methator is contraindicated in patients with severe renal insufficiency, marked liver parenchymal damage or blood dyscrasias. Hypersensitivity to pyrimethamine or sulfonamides. Patients with documented megaloblastic anemia due to folate deficiency. Infants less than 2 months of age. Pregnancy at term and during the nursing period because sulfonamides pass the placenta and are excreted in the milk and may cause kernicterus.

DOSAGE AND ADMINISTRATION (See INDICATIONS AND USAGE)
(a) Treatment of Acute Attack of Malaria
A single dose of the following number of MethatorTablets is used
in sequence with quinine or alone:
Adults 2-3 Tablets
9 – 14 years 2 Tablets
4-8 years 1 Tablet
Under 4 years ½ Tablet

 






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