Diclofenac Potassium & Paracetamol are NSAIDs which inhibit cyclo-oxygenase enzyme, responsible for formation of prostaglandins. Thus both Diclofenac Potassium & Paracetamol in DOLOCIDE KP have "synergistic" actions as Analgesic, Antipyretic & Anti-inflammatory agents.
Diclofenac Potassium is well absorbed orally, 99% protein bound, distributed throughout the body fluids, metabolized in liver and excreted in both urine and bile. The plasma t1/2 is nearly 2 hours.
Paracetamol is well absorbed orally, only about 1/3rd is protein bound in plasma and uniformly distributed in the body. Paracetamol is conjugated with glucuronic acid sulfate and is excreted rapidly in urine. Plasma t1/2 is 2-3 hours. Effects, after an oral dose, last for 3-5 hours.