Rifampicin Capsules

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Rifampicin Capsules

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Rifampicin Capsules

Product description

Details:

Rifampicin is bactericidal against a wide range of micro-organisms and interferes with their synthesis of nucleic acides by inhibiting DNA-dependent RNA polymerase. It has the ability to kill intracellular or the spectrum of activity organisms. The spectrum of activity including Mycobacterium tuberculosis and M. leprea staphylococci,. Neisseria meningitides, N. gonorrhoeae, Legionella spp., Rifampicin Chlamydia trachomatis and some anerobic bacteria. At high concentrations it is active against some viruses.
Product Packaging
Rifampicin capsules can be packaged as:
10 capsules / blister / box,
10 capsules / blister, 10 blisters / box,
1,000 capsules / plastic jar,
or according to the customer's requirements.
  • Antibiotic
  • Rifampicin
  • China
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Product Dosages

    

NameFormDosageCode
Rifampicin Capsule 150mg 1000.2607
Rifampicin Capsule 300mg 1000.2599
Additional Information

RIFATOR
Rifampicin Capsules 300mg

COMPOSITION
Each capsule contains: Rifampicin B.P. …. 300mg

APPEARANCE
A practically odourless reddish brown or brownish red crystalline powder in capsules

PHARMACOLOGY
It is bactericidal against a wide range of micro-organisms and interferes with their synthesis of nucleic acides by inhibiting DNA-dependent RNA polymerase. It has the ability to kill intracellular or the spectrum of activity organisms. The spectrum of activity including Mycobacterium tuberculosis and M. leprea staphylococci,.Neisseria meningitides, N. gonorrhoeae, Legionella spp., Rifampicin Chlamydia trachomatis and some anerobic bacteria. At high concentrations it is active against some viruses. MICs for the sensitive organisms (Chlamydia, staphylo cocci) tend to range from about 0.01 to 0.02 ug per ml. while the MIC for most susceptible mycobacteria ranges from 0.1 to 2 ug per ml.

PHARMACOKINETICS
Rifampicin is readily absorbed from the gastro intestinal tract and peak plasma concentrations of about 7 to 10 ug per ml have been reported 2 to 4 hours after a dose of 600mg but there may be considerable interindividual variation. Approximately 80% world bound to plasma proteins. It is widely distributed in body tissues and fluids and diffuses into the cerebrospinal fluid when the meniges are inflamed and crosses the placenta and distribute in breast milk. Half-lives for rifampicin have been reported to range initially from 2 to 5 hours. It is rapidly metabolized in the liver and excreted in the bile. Meanwhile up to 30% may be excreted in the urine.

INDICATION
Rifampicin is used, notably is combination with Isoniazide and Pyrazinamide as a component of multidrug regimens for the treatment of tuberculosis and with dapsone and clofazimine in the treatment of leprosy. Other uses include treatment of staphylococcal infections, brucellosis, and legionnaires disease and the prophylaxis of haemophilus and meningococcal meningitis.

ADVERSE EFFECTS
Rifampicin is usually well tolerated. The main adverse effects are a flu-like syndrome and a cutaneous syndrome. Hepatotoxicity also occurs. Gastro-intestinal adverse effects include nausea, vomiting, anorexia, diarrhea, and epigastric distress.

PRECAUTIONS
Liver function should be checked before and during treatment, blood counts should be monitored during prolonged treatment and in patients with hepatic disorders.

ADMINISTRATION & DOSAGE
The usual adults dose of rifampicin is 600mg daily by mouth. Preferably on an empty stomach orally administration on an empty stomach in single daily doses of 10mg per kg body-weight (maximum 600mg) to children and adults is recommended. The maximum dose is considered to be 900mg.

STORAGE
Store in airtight containers, protected from light in a cool place.

PRESENTATION
-Blisters of 10 Capsules, 10 blisters per box

SHELF LIFE
3 years

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